The endocannabinoid system regulates synaptic transmission in nucleus accumbens by increasing DAGL-alpha expression following short-term morphine withdrawal

Wang XQ; Ma, J; Cui, W; Yuan, WX; Zhu, G; Yang, Q; Heng, LJ; Gao, GD.

(2016) Br J Pharmacol . Apr;173(7):1143-53.

Link to abstract

The endocannabinoid (eCB) system is involved in pathways that regulate drug addiction and eCB-mediated synaptic plasticity has been linked with addictive behaviours. Here, we investigated the molecular mechanisms underlying the changes in eCB-dependent synaptic plasticity in the nucleus accumbens core (NAcc) following short-term withdrawal from repeated morphine treatment.