Boorman E, Zajkowska Z, Ahmed R, Pariante CM, and Zunszain PA

(2016) Psychopharmacology (Berl) . May;233(9):1591-604.

Link to abstract

The endocannabinoid (eCB) system, an endogenous lipid signaling system, appears to be dysregulated in depression. The role of endocannabinoids (eCBs) as potent immunomodulators, together with the accumulating support for a chronic low-grade inflammatory profile in depression, suggests a compelling hypothesis for a fundamental impairment in their intercommunication, in depression.