Greene NZ, Wiley JL, Yu Z, Clowers BH and Craft RM

(2018) Psychopharmacology (Berl) 235: 3289-3302

Link to abstract

Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development.