Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U and Henthorn TK

Br J Clin Pharmacol (2020) 86: 611-619

Link to abstract

Population pharmacokinetic models of Δ9-tetrahydrocannabinol (THC) have been developed for THC plasma and blood concentration data. Often, only the metabolites of THC are measurable when blood samples are obtained. Therefore, we performed a population pharmacokinetic analysis of THC, 11-OH-THC and THCCOOH plasma concentration data from a Phase I clinical trial of THC smoking.