N-Acyl Amino Acids (Elmiric Acids): Endogenous Signaling Molecules with Therapeutic Potential
Burstein SH (2018) Mol Pharmacol, 93: 228-238. Link to abstract The subject of N-acyl amino acid conjugates has been rapidly growing…
Cannabidiol, a novel inverse agonist for GPR12
Brown, KJ, AS Laun and ZH Song (2017) Biochem Biophys Res Commun. Nov 4;493(1):451-454. Link to abstract GPR12 is a…
The Endocannabinoid System and Its Therapeutic Exploitation in Multiple Sclerosis: Clues for Other Neuroinflammatory Diseases
Chiurchiu V, van der Stelt M, Centonze D and Maccarrone M. (2018) Prog Neurobiol, 160: 82-100. Link to abstract Multiple…
Maternal high-fat diet induces sex-specific endocannabinoid system changes in newborn rats and programs adiposity, energy expenditure and food preference in adulthood
Dias-Rocha CP, Almeida MM, Santana EM, Costa JCB, Franco JG, Pazos-Moura CC and Trevenzoli IH (2018) J Nutr Biochem, 51:…
Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy
Wortley, MA, JJ Adcock, ED Dubuis, SA Maher, SJ Bonvini, I Delescluse, R Kinloch, G McMurray, C Perros-Huguet, M Papakosta,…
Inhibition of Wnt/beta-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer
Proto, MC, D Fiore, C Piscopo, S Franceschelli, V Bizzarro, C Laezza, G Lauro, A Feoli, A Tosco, G Bifulco,…
Cardiovascular effects of marijuana and synthetic cannabinoids: The good, the bad, and the ugly
Pal Pacher, Sabine Steffens, György Haskó, Thomas H. Schindler & George Kunos (2017) Nature doi:10.1038/nature23272 Link to abstract Dysregulation of…
Natural (9-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB1 receptor
Malyshevskaya, O, K Aritake, MK Kaushik, N Uchiyama, Y Cherasse, R Kikura-Hanajiri and Y Urade (2017) Sci Rep. 7: 10516…
Crystal structures of agonist-bound human cannabinoid receptor CB1
Tian Hua, Kiran Vemuri, Spyros P. Nikas, Robert B. Laprairie, Yiran Wu, Lu Qu, Mengchen Pu, Anisha Korde, Shan Jiang,…
Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware
Angelini, R, DA Argueta, D Piomelli and NV DiPatrizio (2017) Cannabis Cannabinoid Res 2: 123-132 Link to abstract Fatty acid…
GPR3 and GPR6, novel molecular targets for cannabidiol
Laun AS and Song ZH 2017) Biochem Biophys Res Commun. pii: S0006-291X(17)31074-4. doi: 10.1016/j.bbrc.2017.05.165 Link to abstract GPR3 and GPR6…
Cannabidiol reduces ethanol consumption, motivation and relapse in mice
Viudez-Martinez A, Garcia-Gutierrez MS, Navarron CM, Morales-Calero MI, Navarrete F, Torres-Suarez AI, and Manzanares J (2018) Addict Biol. Jan;23(1):154-164 Link…
Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant
Sloan ME, Gowin JL, Yan J, Schwandt ML, Spagnolo PA, Sun H, Hodgkinson CA, Goldman D and Ramchandani VA (2018)…
Neurocognition and subjective experience following acute doses of the synthetic cannabinoid JWH-018: a phase 1, placebo-controlled, pilot study
Theunissen EL, Hutten N, Mason NL, Toennes SW, Kuypers KPC, de Sousa Fernandes Perna EB and Ramaekers JG (2018) Br…
Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism
Medeiros D, Silva-Goncalves LC, da Silva AM, Dos Santos Cabrera MP and Arcisio-Miranda M (2018) Sci Rep, 7: 41362. Link…
Themed Issue in: Trends in Pharmacological Sciences
Cannabidiol Claims and Misconceptions Ethan Russo, MD, Editor (2017) Trends in Pharmacological Sciences
BOOK: Endocannabinoid Signaling: Methods and Protocols
Mauro Maccarrone, Editor ISBN: 978-1-4939-3539-0 This volume encompasses all major methodologies to interrogate endocannabinoid systems (ECS) and endocannabinoids (eCBs) signaling….
BOOK: The Analytical Chemistry of Cannabis
The Analytical Chemistry of Cannabis Brian Thomas & Mahmoud ElSohly ISBN: 9780128046463 A volume in the Emerging Issues in Analytical Chemistry series, The…
α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility
Fisette A, Tobin S, Decarie-Spain L, Bouyakdan K, Peyot ML, Madiraju SR, Prentki M, Fulton S, and Alquier T. (2016)…
Crystal Structure of the Human Cannabinoid Receptor CB1
Tian Hua , Kiran Vemuri , Mengchen Pu , Lu Qu , Gye Won Han , Yiran Wu , Suwen…
Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoyl-ethanolamine in development of neurons and cognitive function
Ji-Won Lee, Bill X. Huang, HeungSun Kwon, Md Abdur Rashid, Giorgi Kharebava, Abhishek Desai, Samarjit Patnaik, Juan Marugan and Hee-Yong…
Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose
Seeman, P. (2016) Transl Psychiatry. Oct 18;6(10):e920. doi: 10.1038/tp.2016.195. Link to abstract Although all current antipsychotics act by interfering with…
Monoacylglycerol enriched oil increases EPA/DHA delivery to circulatory system when orally administered to humans with induced lipid malabsorption conditions
Cruz-Hernandez C, Destaillats F, Thakkar SK, Goulet L, Wynn E, Grathwohl D, Roessle C, de Giorgi S, Tappy L, Giuffrida…
BOOK: Handbook of Cannabis
HANDBOOK OF CANNABIS Roger Pertwee, Editor ISBN: 9780198792604 Truly global in scope and with contributions from leading researchers around the…
Cannabinoid-Induced Changes in Respiration of Brain Mitochondria
Fisar Z, Singh N, Hroudova (2014) Toxicol Lett . Nov 18;231(1):62-71. Link to abstract Cannabinoids exert various biological effects that…
Ethanol downregulates N-acyl phosphatidylethanolamine-phospholipase D expression in BV2 microglial cells via epigenetic mechanisms
Correa F, De Laurentiis A, and Franchi AM 2016) Eur J Pharmacol, 782: 224-233 Link to abstract Excessive ethanol drinking…
Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol
Patel RR, Barbosa C, Brustovetsky T, Brustovetsky N and Cummins TR Link to abstract Mutations in brain isoforms of voltage-gated…
Enzymatic characterization of recombinant rat DDHD2, a soluble diacylglycerol lipase
Araki M, Ohshima N, Aso C, Konishi A, Obinata H, Tatei K, and Izumi T (2016) J Biochem . Nov;160(5):269-279….
Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus
Stempel AV, Stumpf A, Zhang HY, Ozdogan T, Pannasch U, Theis AK, Otte DM, Wojtalla A, Racz I, Ponomarenko A,…
Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor
Zou Z, Lu Y, Zha Y, and Yang H (2016) J Mol Neurosci. Aug;59(4):493-503 Link to abstract Inflammation plays a…
Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer
Cajanus, K, Holmstrom, EJ, Wessman, M, Anttila, V, Kaunisto, MA, Kalso, E (2016) Pain 157: 361-369 Link to abstract Fatty…
Involvement of Endocannabinoids in Alcohol “Binge” Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists
Zhou, Y, Huang, T, Lee, F, Kreek, MJ (2016) Alcohol Clin Exp Res 40: 467-473 Link to abstract The endocannabinoid…
Type 2 cannabinoid receptor contributes to the physiological regulation of spermatogenesis
Di Giacomo D, De Domenico E, Sette C, Geremia R, and Grimaldi P (2015) FASEB J . Apr;30(4):1453-63. Link to…
Pioglitazone inhibits the development of hyperalgesia and sensitization of spinal nociresponsive neurons in type 2 diabetes
Griggs RB, Donahue RR, Adkins BG, Anderson KL, Thibault O, and Taylor BK (2015) J Pain. Mar;17(3):359-73. Link to abstract…
Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner
Lowin T, Apitz M, Anders S, and Straub RH (2015) Arthritis Res Ther, 17(1):321. Link to abstract The endocannabinoid system…
N-Acylethanolamines Bind to SIRT6
Rahnasto-Rilla M, Kokkola T, Jarho E, Lahtela-Kakkonen M, and Moaddel R (2016) Chembiochem, 17(1):77-81. Link to abstract Sirtuin 6 (SIRT6)…
Striatal adenosine-cannabinoid receptor interactions in rats overexpressing adenosine A2A receptors
Chiodi V, Ferrante A, Ferraro L, Potenza RL, Armida M, Beggiato S, Pezzola A, Bader M, Fuxe K, Popoli P,…
Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-Induced Neuroinflammation
Grabner GF, Eichmann TO, Wagner B, Gao Y, Farzi A, Taschler U, Radner FP, Schweiger M, Lass A, Holzer P,…
THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia
Aguilar DD, Giuffrida A, and Lodge DJ (2016) J Psychopharmacol, 30(2):169-81. Link to abstract Cannabis use has been associated with…
Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus
Li Y and Kim J (2015) Neuroscience, 311:253-67. Link to abstract In the brain, CB1 cannabinoid receptors primarily mediate the…
Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?
Boorman E, Zajkowska Z, Ahmed R, Pariante CM, and Zunszain PA (2016) Psychopharmacology (Berl) . May;233(9):1591-604. Link to abstract The…
Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons
de Salas-Quiroga A, Diaz-Alonso J, Garcia-Rincon D, Remmers F, Vega D, Gomez-Canas M, Lutz B, Guzman M, and Galve-Roperh I…
Themed Issue in: Cannabis
Nature – NATUREOutlook – Cannabis Supplement (2015) Michelle Grayson, Ed. Nature, Vol. 525 No. 7570_supp ppS1-S18. Cannabis has been cultivated for millennia, but…
Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors
Aghaei I, Rostampour M, Shabani M, Naderi N, Motamedi F, Babaei P, and Khakpour-Taleghani B 2015) Epilepsy Res, Vol. 117,…
beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling
Anderson GR, Aoto J, Tabuchi K, Foldy C, Covy J, Yee AX, Wu D, Lee SJ, Chen L, Malenka RC,…
The Scientist – A Fundación CANNA Film
https://youtu.be/csbJnBKqwIw
Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis
Wen J, Ribeiro R, Tanaka M, and Zhang Y (2015) Neuropharmacology, 99, 196-209. Link to abstract Alpha/beta-hydrolase domain 6 (ABHD6)…
Signaling Mechanism of Cannabinoid Receptor-2 Activation-Induced beta-Endorphin Release
Gao, F, Zhang, LH, Su, TF, Li, L, Zhou, R, Peng, M, Wu, CH, Yuan, XC, Sun, N, Meng, XF,…
Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor
Taylor, L, Christou, I, Kapellos, TS, Buchan, A, Brodermann, MH, Gianella-Borradori, M, Russell, A, Iqbal, AJ & Greaves, DR. (2015)…
Cannabinoid CB1 Receptor Agonists Do Not Decrease, but may Increase Acoustic Trauma-Induced Tinnitus in Rats
Zheng, Y., Reid, P., and Smith, P.F. (2015) Front Neurol 6:60 Link to abstract Tinnitus has been suggested to arise…
Endocannabinoids are conserved inhibitors of the Hedgehog pathway
Khaliullina, H., Bilgin, M., Sampaio, J.L., Shevchenko, A., and Eaton, S. (2015) Proc.Natl.Acad.Sci.U.S.A. 112 (11): 3415-3420. Link to abstract Hedgehog…
Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies
Mauro Maccarrone, Manuel Guzmán, Ken Mackie, Patrick Doherty & Tibor Harkany Nature Reviews Neuroscience volume 15, pages 786–801(2014) Link to…
Arachidonoyl-ethanolamide activates endoplasmic reticulum stress-apoptosis in tumorigenic keratinocytes: Role of cyclooxygenase-2 and novel J-series prostamides
Soliman E, Henderson KL, Danell AS, Van Dross (2015) R. Mol Carcinog. [Epub ahead of print] Link to abstract Non-melanoma…
Endocannabinoid signalling and the deteriorating brain
Vincenzo Di Marzo, Nephi Stella & Andreas Zimmer Nature Reviews Neuroscience volume 16, pages 30–42(2015) Link to abstract Ageing is…
The endocannabinoid system regulates synaptic transmission in nucleus accumbens by increasing DAGL-alpha expression following short-term morphine withdrawal
Wang XQ; Ma, J; Cui, W; Yuan, WX; Zhu, G; Yang, Q; Heng, LJ; Gao, GD. (2016) Br J Pharmacol…
Oleoylethanolamide and Human Neural Responses to Food Stimuli in Obesity
Grosshans M, Schwarz E, Bumb JM, Schaefer C, Rohleder C, Vollmert C et al. (2014) JAMA Psychiatry. Nov;71(11):1254-61. Link to…
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2
Payandemehr B, Ebrahimi A, Gholizadeh R, Rahimian R, Varastehmoradi B, Gooshe M, Aghaei HN, Mousavizadeh K, Dehpour AR. (2015) Prog…
Early phytocannabinoid chemistry to endocannabinoids and beyond
Raphael Mechoulam, Lumír O. Hanuš, Roger Pertwee & Allyn C. Howlett (2014) Nature Reviews Neuroscience volume 15, pages 757–764 Link…
Modulation of plasma N-acylethanolamine levels and physiological parameters by dietary fatty acid composition in humans
Jones PJ; Lin, L; Gillingham, LG; Yang, H; Omar, JM J Lipid Res . 2014 Dec;55(12):2655-64. Link to abstract N-Acylethanolamines…
Hypoximimetic activity of N-acyl-dopamines. N-Arachidonoyl-dopamine stabilizes HIF-1alpha protein through a SIAH2-dependent pathway
Soler-Torronteras R, Lara-Chica M, Garcia V, Calzado MA, Munoz E (2014) Biochim Biophys Acta 1843: 2730-2743 Link to abstract The…
Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans
Lin YH, Chen YC, Kao TY, Lin YC, Hsu TE, Wu YC et al. (2014) Aging Cell 13: 755-764 Link…
Themed issue on: Cannabinoids in Biology and Medicine
Special Issue in Biology and Medicine, Part I British Journal of Pharmacology, Volume 163, Issue 7, Pages 1327-1562, i-xiv. Itai Bab…